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Patients should be advised to seek urgent same-day medical attention (via NHS 111, 999 or A&E) if they experience: Severe, persistent abdominal pain with or without vomiting (potential pancreatitis) Signs of severe allergic reaction Patients should also contact their healthcare professional promptly if they experience: Unexplained weight loss beyond expected therapeutic effect Worsening of autoimmune disease symptoms Persistent gastrointestinal symptoms affecting nutrition or hydration Suspected adverse reactions should be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or the Yellow Card app)

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Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients